Transport of patients with giant disfiguring cranial tumors from Africa to the US for collaborative multidisciplinary treatment
- Department of Neurosurgery, National Brain Aneurysm and Tumor Center, Minneapolis, Minnesota, United States,
- Department of Neurosurgery, Gillette Children’s Specialty Healthcare, Saint Paul, Minnesota, United States,
- Department of Craniofacial and Plastic Surgery, Gillette Children’s Specialty Healthcare, Saint Paul, Minnesota, United States,
- Department of Ophthalmology and Visual Neurosciences, University of Minnesota, United States,
- Superior Medical Experts, Minnesota, United States.
Department of Neurosurgery, National Brain Aneurysm and Tumor Center, Minneapolis, Minnesota, United States,
DOI:10.25259/SNI_923_2020Copyright: © 2021 Surgical Neurology International This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
How to cite this article: Eric Nussbaum1, Patrick Graupman2, Martin Lacey3, Andrew Harrison4, Jodi Lowary1, Jillienne Touchette5, Leslie Nussbaum1. Transport of patients with giant disfiguring cranial tumors from Africa to the US for collaborative multidisciplinary treatment. 19-Apr-2021;12:175
How to cite this URL: Eric Nussbaum1, Patrick Graupman2, Martin Lacey3, Andrew Harrison4, Jodi Lowary1, Jillienne Touchette5, Leslie Nussbaum1. Transport of patients with giant disfiguring cranial tumors from Africa to the US for collaborative multidisciplinary treatment. 19-Apr-2021;12:175. Available from: https://surgicalneurologyint.com/?post_type=surgicalint_articles&p=10732
Background: Giant disfiguring cranial tumors are exceptionally rare and develop over the course of many years, typically in patients who lack access to medical care. Here, we describe four patients who were flown to our center for treatment by a multidisciplinary surgical team, who had previously been turned down for treatment at multiple international centers in Africa, Europe, and the United States (US) due to complexity and financial concerns. The case series describes socioeconomic implications and the feasibility of offering such care to patients from outside the US.
Case Descriptions: Four patients with giant skull disfiguring tumors were flown internationally and treated by a surgical team consisting of a complex cranial neurosurgeon, a craniofacial reconstructive plastic surgeon, and an oculoplastic surgeon. All patients underwent aggressive surgical therapy with the aim of complete tumor removal and simultaneous cranial reconstruction. A patient with osteogenic sarcoma underwent two additional resections in 3 years, with delayed reconstruction. They returned home but ultimately succumbed to the disease. A patient with ossifying fibroma required two follow-up procedures for cosmetic reconstruction and sought asylum in the US, where they remain today. Two additional patients, one with a giant plexiform neurofibroma and one with a cerebellopontine angle meningioma, achieved good results and returned to Africa 1 month and 3 weeks after surgery, respectively.
Conclusion: Resection of giant disfiguring cranial tumors and reconstruction of the impacted region requires an experienced multidisciplinary team. These cases can be managed by transporting such patients from areas without access to medical care to specialized centers able to provide excellent care.
Keywords: Cranial reconstruction, Disfiguring cranial tumors, Tumor resection
Giant disfiguring cranial tumors have become extremely rare due to advances in early tumor detection and generally only occur when patients do not have access to care during the early stages of tumor development.[
A 28-year-old male from Ethiopia presented with a large bilateral mass measuring over 20 cm in its largest dimension arising from the frontal aspect of the left side of his head. The mass had grown rapidly over the previous 2 years, resulting in headaches, nosebleeds, and left-sided blindness.
A catheter angiogram showed portions of the mass that were mildly to moderately vascular. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a 24 cm × 20 cm × 18 cm extra-axial mass centered in the region of the left frontal bone [
Preoperative radiographic images of disfiguring osteosarcoma tumor mass (Case 1). (a) Sagittal view, T1-weighted MRI showing disfiguring tumor obstructing the left eye. (b) Posteroanterior view, CT. (c and d) Axial view, T2-weighted MRI showing well-defined enhancing nodules within the mass. (e) Axial view, CT. (f) Axial view, T1-weighted MRI showing displacement of brain parenchyma.
A bicoronal incision was made to the level of the zygoma and was carried down to the level of the tumor. The scalp flap was reflected forwards and backwards until we reached normal bone posteriorly and nasal brow anteriorly. Cutaneous and subcutaneous bleeding was controlled with bipolar electrocautery. Two holes were drilled through the skull on either side to normal dura and were connected posteriorly and anteriorly, crossing the sagittal sinus. The skull was cracked and lifted, along with the massive tumor mass, in one piece, weighing 17 lbs. Additional tumor was cleared out of the orbit and from the region of the sphenoid wing and temporal fossa. Substantial bleeding from the bone and dura was controlled, with 4 L of blood lost in total. The scalp and skull were closed over two large Jackson-Pratt drains and a portion of the redundant scalp flap was resected. Intraoperative photographs are presented in [
Histopathological examination of the mass revealed a high-grade osteogenic sarcoma with telangiectatic features.
The patient had no neurological defects or serious side effects and returned to Ethiopia where he underwent limited treatment with chemotherapy, but not radiation. At that time, a proton emission tomography (PET) scan had shown the mass to be locally contained without remote spread.
The patient returned 11 months later with a recurrent tumor involving the nasal cavity and orbits. The largest axial dimensions of the anterior component measured 7 × 12 cm. The patient opted to undergo a second operation. The bicoronal incision from the previous surgery was reopened, and the scalp was reflected anteriorly revealing the tumor over the right orbital region. The tumor was resected bluntly with bipolar cautery. Once the tumor was resected, dural repair was placed. The team’s craniofacial reconstructive surgeon performed a mesh cranioplasty. The wound was closed with a Jackson-Pratt drain and nylon sutures, and the patient was taken to the recovery room in stable condition.
The patient returned 26 months later with another large recurrence of the tumor and opted for a third surgery. Before surgery, the patient underwent endovascular particle embolization of the right middle meningeal artery, right accessory meningeal artery, and anterior deep temporal artery, which were supplying the tumor. During surgery, the previous bicoronal incision was reopened. The scalp was scarred down to the underlying mesh. Tumor underlying the mesh and other posteriorly located tumor tissue were aggressively removed. The frontal bone, which had been largely replaced by tumor, was removed bilaterally down to the orbital rims. The orbital rims were removed, and orbits were decompressed aggressively to the optic and carotid canals. The sphenoid wing was drilled down bilaterally, as it had been completely involved with the tumor on the right side. Surgeons continued down into the pterygopalatine fossa and also came down in the midline into the mid-face to the region of the ethmoid sinuses, which were completely filled with tumor tissue.
The patient experienced severe blood loss and intraoperative coagulopathy. This was addressed with activated Factor VII. Some tumor remained in the ethmoid sinus and behind the incision on the left side; this was not removed due to the significant blood loss that had already occurred. The craniofacial reconstructive surgeon using the existing titanium graft from the previous cranioplasty to reconstruct the defect.
The patient was treated with additional rounds of chemotherapy, but after returning to Ethiopia, he succumbed to his disease 9 months later.
A 20-year-old female from Ethiopia presented with a giant skull-based tumor with a massive orbitocranial deformity distorting her facial anatomy and right eye.
Diagnostic angiography, CT, and MRI revealed a giant, moderately hypervascular, multilobulated, and peripherally calcified expansile mass lesion which appeared to arise from the skull base and occupy the entire nasal cavity, maxillary sinus, and ethmoid sinus regions [
The patient underwent resection of the tumor through a subcranial transfacial approach. A bicoronal incision was carried down, preserving the galeal layer for possible use as a graft later. An incision was made over the face and nose to expose the front of the tumor. We broke through the thin bony shell and entered the multiloculated cystic tumor cavity. Fluid was drained and the operating microscope was brought into the field. This allowed us to work circumferentially to remove the entire solid tumor components all the way back to the circumferential bony shell. This left a massive cavity measuring over 15 cm in diameter. All soft tissues were removed and bone was drilled down. The lateral wall of the tumor was drilled, allowing for replacement of the globe to a more natural position. Bone was also drilled off the medial wall to decompress the lesion. The dura was never entered. Calvarial bone grafts were harvested by taking a large frontal parasagittal craniotomy.
A craniofacial reconstructive surgeon with the help of an oculoplastic specialist completed a complex reconstruction. We used the bone grafts to reconstruct a new orbit and mid-face. Repair of the skull bone and scalp was undertaken in a second surgery by our craniofacial/plastic surgeon.
Histopathological examination demonstrated an ossifying fibroma with a proliferation of plump spindle cells, mostly hypocellular, with focal hypercellular areas. Production of woven bone was seen intermittently with the spindle cells. The spindle cells showed focal areas of storiform arrangement with focal osteoblastic rimming. The final diagnosis was fibrous dysplasia.
The patient remained neurologically and physically stable throughout the follow-up period, with the exception of increasing headaches and occasional nosebleeds. Follow-up PET and MRI at 1 month and 10 months postoperative were stable and showed no evidence of tumor growth. The patient has been followed for 10 years with mild interval progression of bony changes but no clear evidence of tumor regrowth. During this time, she underwent one additional delayed cosmetic procedure for her left eye.
A 39-year-old man presented with extensive bone and soft-tissue changes related to a large plexiform neurofibroma involving the left temporal region, underlying bone, and dura. He had no neurological deficit but did have worsening headaches. The patient traveled from Ethiopia for surgical repair.
CT scan of the brain including bone windows and thin cut imaging through the temporal bones demonstrated extensive bony erosion with scalloping of the bone edges compatible with the long-standing presence of the left temporal mass which itself involved the subcutaneous tissue, temporalis muscle, and dura. There was no appreciable intradural extension of the lesion. These findings were confirmed on MRI, which revealed the heterogeneously enhancing mass involving the soft tissue, bone, and dura of the left temporal region. Diagnostic angiography revealed enlargement of the superficial temporal and middle meningeal arteries, which were embolized with polyvinyl alcohol the day before surgery.
A single-stage operation was carried out. Our craniofacial team resected a large amount of redundant soft tissue and skin overlying the relatively hypervascular mass. The tumor was removed en bloc, and thickened underlying dura was also resected. The underlying bone was severely thinned, and titanium cranioplasty was used for reconstruction.
Pathological examination was compatible with a plexiform neurofibroma.
Postoperatively, the patient did well without new deficits. After 1 month’s recovery and removal of all sutures, the patient was able to return home. Six-month follow-up was carried out remotely, and the patient was doing well without regrowth of tumor or new deficits. The patient was offered a second surgery to correct cosmetic appearance, but was happy with the result and declined to return.
A 44-year-old woman from Nigeria presented with worsening headaches and balance difficulties.
The patient traveled to our center where MRI revealed a 6 cm mass lesion involving the cerebellopontine angle with overlying bony hyperostosis. CT scan with bone windows demonstrated the marked hyperostosis resulting in deformity of the overlying skull, which was well hidden by the patient’s hair on physical examination. There was marked deformity of the cerebellum and brainstem by the extra-axial mass, which displaced the basilar artery and extended out along the internal auditory canal.
The patient underwent suboccipital craniotomy with resection of the tumor. At the time of surgery, the majority of the tumor was removed, but a small amount was left due to adherence to the basilar artery. The bony hyperostosis was aggressively drilled away, and titanium mesh was utilized to cover the defect.
Pathological examination demonstrated a meningioma.
The patient tolerated the procedure well, though she developed partial fourth cranial nerve palsy after the surgery. Otherwise, she suffered no new deficits. She returned home 6 weeks after surgery, and follow-up imaging at 18 months was stable. Her fourth cranial nerve palsy had fully resolved.
Here, we demonstrate the successful treatment of giant skull deforming tumors in 4 patients from Africa by a multidisciplinary team. Giant skull deforming tumors are exceptionally rare with limited cases reported in recent history.[
Common risks and symptoms associated with giant skull deforming tumors include headaches,[
Reported methods of reconstruction include the use of myocutaneous skin flap reposition,[
Due to the complexity and rarity of giant skull deforming tumors, each procedure must be planned and performed on a case-by-case basis. Imaging studies should be undertaken to help establish the extent of the tumor and guide surgical resection. As we do in all cases, the goals of surgery balanced maximal safe surgical resection with a desire to avoid permanent neurological deficit or disability. Although we knew that the only chance to achieve a cure in these cases might be the initial surgery (given the barriers to having the patients return to the US for repeat operations), we also felt that a permanent disability would be an unacceptable complication, particularly for individuals returning to countries with limited medical and social support resources. Three of our patients had been “home bound” for years before surgery due to the disfiguring nature of their tumors. In these cases, it was hoped that simply restoring a “near-normal” cosmetic result would allow the patients to reenter society, radically improving their quality of life.
Giant skull deforming tumors are exceptionally rare and there is no definitive consensus on treatment practices, particularly for patients from countries with such limited medical resources. Historically, neurosurgeons have traveled to areas in sub-Saharan Africa, Latin America, and the Caribbean to train neurosurgeons locally, where an estimated 22 million additional neurosurgical procedures are needed for patients.[
Interestingly and unexpectedly, our provision of care to these patients received both positive and negative responses by the lay community in the Twin Cities. Treatment costs for the patients described here ranged from $125,000 to $275,000. The cross-continental agreement allowed the surgeons and hospital to offer their services free of charge to the patient. When word of the surgeries was made public by the local media,[
Giant disfiguring cranial tumors are extremely rare, primarily occurring in patients who are unable or unwilling to access care during the early stages of tumor development. Resection of such large masses can lead to substantial blood loss, and reconstruction of the impacted skull region and facial features requires precise management. Here, we show the successful treatment of four giant disfiguring cranial tumors by a multidisciplinary team. With proper caution and resources to send patients to a center able to provide excellent care, simultaneous surgical resection and craniofacial reconstruction by a multidisciplinary surgical team are a viable treatment option for these rare cases.
Patients’ consent not required as patients’ identities were not disclosed or compromised.
This manuscript was supported by a grant from the United Hospital Foundation.
Jillienne Touchette is CEO and has ownership interest in Superior Medical Experts. All other authors declare no conflicts of interest.
The authors acknowledge Superior Medical Experts for research and drafting assistance.
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