Relative risk meta-analysis

Stratum	Table (exposed +ve, control +ve, exposed -ve, control -ve)		
1	0	2	46	52	Gory 2018	
2	19	14	83	6	Martini 2019	
3	0	1	44	44	Nishi 2018	
4	3	7	121	112	Lapergue 2016	
5	4	14	36	55	P.F. Xing 2020	
6	2	6	34	55	Maegerlein 2017	
7	3	5	25	29	Jeon 2020	
8	3	5	69	94	Alex Brehm 2019	
9	6	7	41	63	Stapleton 2018	
10	11	5	153	97	Hesse 2018	
11	7	5	127	131	Turk 2019	
12	33	13	835	499	Alawieh 2019	
13	18	54	189	914	Bernsen 2019	
14	13	4	64	116	Atchaneeyasakul 2020	

Stratum	Relative risk	95% CI (Koopman)		
1	0.212598	0	2.191576	Gory 2018 [CC = treatment arm]	
2	0.266106	0.164199	0.449811	Martini 2019	
3	0.335821	0	3.858922	Nishi 2018 [CC = treatment arm]	
4	0.41129	0.11781	1.423223	Lapergue 2016	
5	0.492857	0.177839	1.29661	P.F. Xing 2020	
6	0.564815	0.133945	2.281652	Maegerlein 2017	
7	0.728571	0.204135	2.525285	Jeon 2020	
8	0.825	0.222571	3.019752	Alex Brehm 2019	
9	1.276596	0.472664	3.401857	Stapleton 2018	
10	1.368293	0.514165	3.696152	Hesse 2018	
11	1.420896	0.487863	4.15295	Turk 2019	
12	1.497341	0.805326	2.794687	Alawieh 2019	
13	1.558776	0.934285	2.569541	Bernsen 2019	
14	5.064935	1.809356	14.346343	Atchaneeyasakul 2020	

Stratum	Standardized effect	Variance	% Weights (fixed, random)		
1	-1.54835	infinity	2.106076	2.277031	Gory 2018 [CC = treatment arm]	
2	-1.323859	0.066091	20.684769	10.492731	Martini 2019	
3	-1.091177	infinity	1.344965	2.196885	Nishi 2018 [CC = treatment arm]	
4	-0.888456	0.404019	6.312418	6.644695	Lapergue 2016	
5	-0.707536	0.256849	9.079121	7.956476	P.F. Xing 2020	
6	-0.571257	0.523143	3.935177	5.773244	Maegerlein 2017	
7	-0.31667	0.411749	3.99042	6.592821	Jeon 2020	
8	-0.192372	0.442541	3.720392	6.352386	Alex Brehm 2019	
9	0.244197	0.253514	4.969267	8.027558	Stapleton 2018	
10	0.313564	0.253209	5.447717	8.018161	Hesse 2018	
11	0.351287	0.298467	4.38524	7.56897	Turk 2019	
12	0.403691	0.10075	14.449948	9.913981	Alawieh 2019	
13	0.443901	0.066611	16.81158	10.432328	Bernsen 2019	
14	1.622341	0.279	2.76291	7.752733	Atchaneeyasakul 2020	

Fixed effects (Mantel-Haenszel, Rothman-Boice)
Pooled relative risk = 1.035387 (95% CI = 0.817692 to 1.311039)
Chi2 (test relative risk differs from 1) = 0.083379  (df = 1)  P = 0.7728
Non-combinability of studies
Cochran Q = 47.71798  (df = 13)  P < 0.0001
Moment-based estimate of between studies variance = 0.618626
I2 (inconsistency) = 72.8% (95% CI = 48.8% to 82.8%) 
Random effects (DerSimonian-Laird)
Pooled relative risk = 0.908369 (95% CI = 0.537542 to 1.535015)
Chi2 (test relative risk differs from 1) = 0.1289  (df = 1)  P = 0.7196
Bias indicators
Begg-Mazumdar: Kendall's -0.274725  P = 0.1572
Egger: bias = 0.136227 (95% CI = -2.353892 to 2.626346)  P = 0.9071
Harbord-Egger: bias = -1.341719 (92.5% CI = -4.011166 to 1.327728)  P = 0.3465