Holmes tremor in a patient with progressive multifocal leukoencephalopathy

Vimal Raj Nitish Gunness, Georges Dooms, Bernd Wauschkuhn, Wolfgang Feiden, Frank Hertel

Date of publication: 05-Sep-2014

Background:Progressive multifocal leukencephalopathy (PML) is a rare, sometimes fatal viral disease in patients with primary or secondary immunosuppression.

Long-term follow-up of deep brain stimulation of peduncolopontine nucleus in progressive supranuclear palsy: Report of three cases

Domenico Servello, Edvin Zekaj, Christian Saleh, Claudia Menghetti, Mauro Porta

Date of publication: 05-Sep-2014

Background:Progressive supranuclear palsy (PSP) is a neurodegenerative disease due to mitochondrial dysfunction. The PSP syndrome presents generally with gait disorder, Parkinsonism, ophthalmoparesis and cognitive alteration. Few reports exist on deep brain stimulation (DBS) in patients with atypical Parkinsonism. The aim of our study was to evaluate further the potential role of DBS in PSP.

Diagnostic yield and morbidity by neuronavigation-guided frameless stereotactic biopsy using magnetic resonance imaging and by frame-based computed tomography-guided stereotactic biopsy

Masamitsu Nishihara, Naoya Takeda, Tomoaki Harada, Keiji Kidoguchi, Shoutarou Tatsumi, Kazuhiro Tanaka, Takashi Sasayama, Eiji Kohmura

Date of publication: 05-Sep-2014

Background:We compared the diagnostic yield and morbidity by frame-based computed tomography-guided stereotactic biopsy (CTSTB) with Brown-Roberts-Wells (BRW) unit and by neuronavigation-guided frameless stereotactic biopsy (NSTB) using magnetic resonance imaging (MRI).

Totally extradural spinal en plaque meningiomas – Diagnostic dilemmas and treatment strategies

Amey Savardekar, Debarshi Chatterjee, Debajyoti Chatterjee, Sivashanmugam Dhandapani, Sandeep Mohindra, Pravin Salunke

Date of publication: 28-Aug-2014

Background:Meningiomas are the second most common intraspinal tumors, constituting ~25% of all intraspinal tumors; however, in the context of extradural spinal lesions, the diagnosis of meningioma is an uncommon one. Purely extradural spinal meningiomas, especially of the en plaque variety, frequently mimic metastatic disease and may result in inadequate therapy.

Multidisciplinary in-hospital teams improve patient outcomes: A review

Nancy E. Epstein

Date of publication: 28-Aug-2014

Background:The use of multidisciplinary in-hospital teams limits adverse events (AE), improves outcomes, and adds to patient and employee satisfaction.

Hemostasis and other benefits of fibrin sealants/glues in spine surgery beyond cerebrospinal fluid leak repairs

Nancy E. Epstein

Date of publication: 28-Aug-2014

Background:Fibrin sealants (FS)/glues (FG) are primarily utilized in spinal surgery to either strengthen repairs of elective (e.g., intradural tumors/pathology) or traumatic cerebrospinal fluid (CSF) fistulas. Here, additional roles/benefits of FS/FG in spine surgery are explored; these include increased hemostasis, reduction of scar, reduction of the risk of infection if impregnated with antibiotics, and its application to restrict diffusion and limit some of the major complications attributed to the controversial “off-label” use of bone morphogeneitc protein (rhBMP-2/INFUSE).

Bilateral neurological deficits following unilateral minimally invasive TLIF: A review of four patients

Alexander T. Nixon, Zachary A. Smith, Cort D. Lawton, Albert P. Wong, Nader S. Dahdaleh, Antoun Koht, Richard G. Fessler

Date of publication: 28-Aug-2014

Background:Minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) is commonly used for the treatment of degenerative lumbar spinal disorders. The rate of postoperative neurological deficits is traditionally low. New neurological postoperative complications may be underreported. We report our infrequent rate of MI-TLIF procedures complicated by postoperative weakness.

Commentary: Unnecessary preoperative epidural steroid injections lead to cerebrospinal fluid leaks confirmed during spinal stenosis surgery

Nancy E. Epstein

Date of publication: 28-Aug-2014

Background:Increasingly, older patients with severe spinal stenosis/instability undergo multiple unnecessary preoperative epidural spinal injections (ESI), despite their risks and lack of long-term benefits. Here we add to the list of risks by showing how often preoperative ESI lead to punctate cerebrospinal fluid (CSF) fistulas documented during subsequent surgery (e.g. multilevel laminectomies with non-instrumented fusions).

Neurological outcome in a series of 58 patients operated for traumatic thoracolumbar spinal cord injuries

Mauro Dobran, Maurizio Iacoangeli, Lucia Giovanna Maria Di Somma, A. Di Rienzo, Roberto Colasanti, Niccolò Nocchi, Lorenzo Alvaro, Elisa Moriconi, Davide Nasi, Massimo Scerrati

Date of publication: 28-Aug-2014

Background:Traumatic thoracolumbar spinal fractures represent approximately 65% of all traumatic spinal fractures and are frequently associated to permanent disability with significant social and economic impact. These injuries create severe physical limitations depending on neurological status, level of fracture, severity of injury, patient age and comorbidities. Predicting neurological improvement in patients with traumatic spinal cord injuries (SCIs) is very difficult because it is related to different preoperative prognostic factors. We evaluated the neurological improvement related to the preoperative neurological conditions and the anatomic level of spinal cord injury.