Abstract

Background:Intracranial prepontine cysts are rare and include epidermoid cysts, arachnoid cysts, and neurenteric cysts. Symptomatic prepontine cysts may require surgical intervention. Reports of spontaneous resolution of cysts are rare.

Case Description:We describe the case of a young gentleman who presented with headache and fever. Magnetic resonance imaging of the brain identified a prepontine lesion with features consistent with epidermoid cyst. During admission, the patient received symptomatic management in addition to empirical antibiotic therapy and dexamethasone. The patient improved symptomatically in the next 48 hours and was discharged. Follow-up imaging at 6 months and 1 year showed significant reduction in size of the lesion.

Conclusion:For asymptomatic prepontine cysts, a close radiological and clinical follow-up may prove useful.

Keywords: Adult brain cyst, MRI brain, prepotine cyst, self-resolution

INTRODUCTION

Prepontine cystic lesions are rare. Common types of cysts reported in this area include epidermoid cysts, arachnoid cysts, and neurenteric cysts.[ 4 6 12 14 ] Symptomatic lesions often require surgical intervention. According to our literature search, spontaneous resolution of a cyst in prepontine area has been reported once before.[ 8 ]

In this report, we describe the case of a young gentleman who presented with headache and fever. A large prepontine cyst was found on magnetic resonance imaging (MRI) with features consistent with epidermoid cyst. The possibility of neurenteric could not be excluded. Patient was treated symptomatically. Follow-up MRI at 1 year showed significant reduction in the size of the cyst.

CASE REPORT

A 41-year-old, right-handed gentleman presented to us in the emergency room with history of severe occipital headache for 4 days. It was constant and moderate to severe in intensity. There was no association with daytime or cough. Headache was associated with several episodes of vomiting. There were no mental status changes, seizure, or complain of motor weakness in any of his limbs.

On examination, he was well oriented to time, place, and person. Signs of meningeal irritation were absent. We also did not find any cranial nerve deficit, papilledema, or long tract signs. Systemic examination was also unremarkable. He had taken symptomatic treatment without much relief in his symptoms. Family history was unremarkable for any intracranial pathologies.

Considering the nature and severity of his symptoms, we obtained an MRI brain with and without contrast. MRI brain showed a midline prepontine cyst with signals identical to cerebrospinal fluid (CSF) on T1 and T2-weighted images [Figures 1a , 2a and 3a ]. Pre-pontine cistern was effaced with significant compression on basilar artery. The cyst showed diffusion restriction. There was no hydrocephalus.

Figure 1

(a) A well-defined extra-axial lesion is identified anterior to the brainstem on this sagittal view, appearing hyper intense relative to brain parenchyma on the T2 weighted image (White arrows). (b) Similar section noted one year later with reduction in mass of the cystic lesion identified in the image a

Figure 2

(a) T1 weighted Brain MRI, this axial section identifies the lesion anterior to the brain stem appearing hyper intense relative to brain parenchyma (White arrows). (b) Similar section noted one year later with reduction in mass of the cystic lesion identified in the image a

Figure 3

(a) T1 weighted image with contrast Brain MRI, this axial section identifies the lesion anterior to the brain stem appearing hyper intense relative to brain parenchyma with no enhancement noticed on contrast (White arrows). (b) Similar section noted one year later with reduction in mass of the cystic lesion identified in the image a

We admitted the patient for further management. He received symptomatic management along with empirical antibiotics. Considering the possibility of chemical meningeal irritation, we also started dexamethasone for 1 week. The patient improved within the next 48 hours and was discharged with a plan for close clinical and radiological follow-up.

After discharge, the patient remained symptom free, and returned with a repeat MRI brain after 1 year. Repeat imaging showed a significant size reduction and decrease in mass effect [Figure 1b , 2b and 3b ].

DISCUSSION

We have described the case of a patient with self-resolving prepontine cyst. Considering the location and radiological features, our top differentials were epidermoid and neurenteric cyst. Epidermoid cysts comprise 0.2–1.8% of primary intracranial tumors.[ 2 ] They arise from ectodermal inclusions formed during the neural tube closure in the third to fifth weeks of gestation at the same time as the optic and octic vessels develop. This explains the frequent occurrence of epidermoid cyst in the cerebellopontine (angle 40–50%)[ 7 9 10 15 ] and the parasellar region (10–15%).[ 5 ] Prepontine area is a rare location for an epidermoid cyst.

Epidermoid cyst on a computed tomography (CT) scan is a round/lobulated mass with a density resembling CSF, calcification is seen in 10% of the cases.[ 11 ] On MRI, hypointensity on T1 and hyperintensity on T2 is noted. Internal heterogeneity on FLAIR images this helps distinguish epidermoid cysts from arachnoid cysts.[ 3 ]

Neurenteric cysts are mostly found in the posterior fossa and are typically midline, anterior to the brainstem.[ 1 13 ] These may arise at the time of notochordal development during the transitory existence of the neurenteric canal. The notochord and foregut fail to separate, causing primitive endodermal cells to be incorporated into the notochord leaving behind a cyst. These cause headache, cranial neuropathies, recurrent aseptic meningitis, and motor and sensory deficits. Best diagnostic tool for a neurenteric cyst is a nonenhancing round or lobulated mass in front of the medulla which appears isointense to hyperintensive on T1, hyperintensive on T2 and also hyperintense on FLAIR images.

CONCLUSION

Although spontaneous resolution of prepontine cysts is rare, in patients who are neurologically intact, symptomatic management with close clinical and radiological follow-up may prove useful.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

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