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S3 motor branch stimulation failure due to nerve fiber burning at the nerve–wire junction: A historical technical note
Date of publication: 27-Feb-2013
Background:Sacral nerve stimulation is a minimally invasive procedure to treat spinal cord injured (SCI) patients with overactive bladder syndrome or nonobstructive urinary retention that is refractory to conservative treatment.
The need in dural graft suturing in Chiari I malformation decompression: A prospective, single-blind, randomized trial comparing sutured and sutureless duraplasty materials
Date of publication: 27-Feb-2013
Background:This study compared the use of two commonly utilized dural closure techniques used in augmentation duraplasty for Chiari malformation I (CM I) and evaluated their efficacy and outcome in terms of quality of life assessments.
Radiation-induced spinal cord glioblastoma with cerebrospinal fluid dissemination subsequent to treatment of lymphoblastic lymphoma
Date of publication: 27-Feb-2013
Background:Radiation-induced glioma arising in the spinal cord is extremely rare. We report a case of radiation-induced spinal cord glioblastoma with cerebrospinal fluid (CSF) dissemination 10 years after radiotherapy for T-cell lymphoblastic lymphoma.
Neurosurgical management of massive cerebellar infarct outcome in 53 patients
Date of publication: 27-Feb-2013
Background:Massive ischemic cerebellar infarct (MICI) is a main source of stroke, which can lead to severe morbidity and mortality. There is no consensus in medical literature for the management of MICI. The choice is made between placing an external ventricular drainage, suboccipital decompressive craniectomy, and removal of necrotic tissue or conservative treatment. There are not many prospective studies, done on this subject.
Mysterious meningioma: Surviving the odds
Date of publication: 27-Feb-2013
Primary balloon angioplasty for symptomatic, high-grade intracranial stenosis
Date of publication: 20-Feb-2013
Background:In light of recent controversy about the safety and efficacy of intracranial stenting, we sought to evaluate our experience with primary balloon angioplasty for symptomatic, high-grade intracranial stenosis.
Useful ‘sliding-lock-knot’ technique for suturing dural patch to prevent cerebrospinal fluid leakage after extended transsphenoidal surgery
Date of publication: 20-Feb-2013
Background:Postoperative cerebrospinal fluid (CSF) leakage is a major problematic complication after extended transsphenoidal surgery (TSS). Watertight closure of the sellar dura with a fascial patch graft is a method of choice for preventing CSF leakage; however, suturing and knotting in a deep and narrow operative field is technically challenging and time consuming. To present a simple and effective knotting technique named the ‘sliding-lock-knot’ technique, in which the knot can easily be slid to the suturing point and tied automatically using only a single string, without loosening.
Sinking of bone flap-looking beyond cosmesis and costs
Date of publication: 20-Feb-2013
Chronic calcified subdural hematoma: Case report and review of the literature
Date of publication: 20-Feb-2013
Background:Calcified chronic subdural hematoma is a rare but known entity, estimated to represent 0.3-2.7% of chronic subdural hematomas. Although surgical treatment is unanimous for chronic subdural hematomas, therein lies some doubt on it being applied to calcified chronic subdural hematomas.
Immunoexcitatory mechanisms in glioma proliferation, invasion and occasional metastasis
Date of publication: 29-Jan-2013
Abstract
There is increasing evidence of an interaction between inflammatory cytokines and glutamate receptors among a number of neurological diseases including traumatic brain injuries, neurodegenerative diseases and central nervous system (CNS) infections. A number of recent studies have now suggested a strong relation between inflammatory mechanisms and excitatory cascades and these may play a role in glioma invasiveness and proliferation.
Chronic inflammation appears to be a major initiating mechanism in most human cancers, involving cell-signaling pathways, which are responsible for cell cycling, cancer cell migration, invasion, tumor aggressiveness, and angiogenesis. It is less well appreciated that glutamate receptors also play a significant role in both proliferation and especially glioma invasion. There is some evidence that sustained elevations in glutamate may play a role in initiating certain cancers and new studies demonstrate an interaction between inflammation and glutamate receptors that may enhance tumor invasion and metastasis by affecting a number of cell-signaling mechanisms. These mechanisms are discussed in this paper as well as novel treatment options for reducing immune-glutamate promotion of cancer growth and invasion.
