Joshua Lucas1, Dorian Kusyk2, Donald Whiting2
  1. MD Program, Drexel University College of Medicine, Philadelphia,
  2. Department of Neurosurgery, Allegheny Health Network, Pittsburgh, Pennsylvania, United States.

Correspondence Address:
Joshua Lucas, MD Program, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States.


Copyright: © 2022 Surgical Neurology International This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Joshua Lucas1, Dorian Kusyk2, Donald Whiting2. Bilateral pallidal DBS for blepharospasm: A case report and review of the literature. 13-May-2022;13:200

How to cite this URL: Joshua Lucas1, Dorian Kusyk2, Donald Whiting2. Bilateral pallidal DBS for blepharospasm: A case report and review of the literature. 13-May-2022;13:200. Available from:

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Background: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) in the treatment of craniocervical dystonia often requires an extended period of stimulation parameter manipulations.

Case Description: We present a patient suffering from debilitating blepharospasm treated with bilateral DBS of the GPi alongside 7 years of stimulation parameter manipulations and a literature review of comparable patients.

Conclusion: Our literature review suggests that a patient’s specific dystonic symptoms can guide stimulation parameter manipulations. Further research regarding trends in stimulation parameters being used in the field for different dystonic symptoms may expedite the stimulation parameter manipulation process.

Keywords: Blepharospasm, Deep brain stimulation, Dystonia, Globus pallidus internus


There is a growing body of evidence regarding deep brain stimulation (DBS) of the globus pallidus internus (GPi) successfully treating dystonic symptoms and dystonic syndromes.[ 41 ] Unfortunately, this success often only comes after an extended period of stimulation parameter manipulations.[ 4 ] This period of outpatient follow-up is both an inconvenience for the patient as well as a challenge for care providers. Furthermore, with a lack of research of the most beneficial stimulation parameters for the specific presentation of symptoms in the patient being treated, this process is currently one of trial and error.

We present a patient suffering from medically refractory craniofacial dystonia, primarily blepharospasm, who was successfully treated with bilateral DBS stimulation of the GPi. Our patient underwent a follow-up period of 7 years and 26 programming visits during which optimal stimulation parameters were gradually reached. We present this case alongside a comprehensive literature review of the various stimulation parameters currently used in DBS-treated blepharospasm. In doing so, our goal is to aide care providers in the stimulation parameter manipulation, alleviating both the patient and the care provider from some of the uncertainty embedded in this process. The patient in question gave us permission to share her clinical history, including programming parameters.


At the time of her DBS implantation, the patient was a 57-year-old Caucasian female who had presented with a several year history of debilitating, treatment resistant blepharospasm. Prior treatments with Botox® injections had not provided relief. After a discussion with the patient about the risks and benefits of surgical intervention, she was amenable to undergoing bilateral GPi DBS electrode placement. Planning and implantation was performed through our center’s standardized protocols, and the target was selected under direct visualization (17 mm lateral to the third ventricle wall, 5 mm below the AC PC on the left, and 3.5 mm below the AC PC).

The patient was followed for 7 years at the time of writing this report. During this period, she had returned for stimulation parameter manipulation 26 times [ Figure 1 ]. Her initial settings were a monopolar configuration with 3.1 V, 130 Hz, and 120 µs on the left electrode and 3.0 V, 130 Hz, and 130 µs on the right. Her maximal settings throughout her follow-up period were 8.1 V, 130 Hz, and 260 µs on the left and 8.0 V, 130 Hz, and 260 µs on the right. Her present settings are 7.0 V, 155 Hz, and 130 µs on the left and 6.7 V, 150 Hz, and 120 µs on the right.

Figure 1:

Stimulation parameter manipulations for currently reported patient. X-axis: postoperative follow-up visit number. Y-axis: volts for amplitude, Hz for frequency, and microseconds for pulse width. Data points for frequency and pulse width are decreased by a factor of 10 for ease of viewing.


The first phase of her programming was targeted toward symptom control. Pulse width and voltage were gradually increased to help control her symptoms while minimizing side effects. This was achieved after about 1 year when she reported that it was “the best (I’ve) felt in a long time.” On sequential visits, there were attempts to decrease the charge density delivered to the patient by decreasing either the voltage, pulse width, or both without allowing for the re-emergence of her blepharospasm.

Throughout her follow-up, the patient also continued to receive Botox® injections and speech therapy. These synergistic interventions allowed for further decreases in delivered charge density.


Above we present a patient suffering from medically refractory craniofacial dystonia. While bilateral DBS stimulation of the GPi was effective, it included a follow-up period of 7 years encompassing 26 programming visits.

We conducted a PubMed literature review using the search terms “DBS AND Meige syndrome,” “DBS AND Blepharospasm,” and “DBS AND (Meige syndrome OR blepharospasm).” In total, 42 articles were included in our review, which included 381 patients. After applying exclusion criteria depicted in [ Figure 2 ], a total of 88 patients were included in our final analysis.[ 1 - 3 , 5 - 14 , 16 - 25 , 27 - 29 , 31 - 46 ]

Figure 2:

Literature review exclusion process.


The average age of the 88 patients was 57 years old (range 26–73). There were 37 females, 48 males, and three instances in which sex was not reported. One patient received unilateral pallidal stimulation. Most patients suffered from more than 1 dystonic symptoms. The average stimulation parameters used in the patients in our literature review were a voltage of 3.2 V (range: 1–6.7), frequency of 146.1 Hz (10–235), and pulse width of 197.1 µs (60–500).

There exists evidence to suggest that elements of the basal ganglia, including the GPi, are organized somatotopically.[ 15 , 26 ] Because of this, we performed an analysis of stimulation parameters for two different groups of patients in our literature review. In Group 1, we included patients who experienced dystonic symptoms isolated to the head. In Group 2, we included patients who experienced dystonic symptoms that extended beyond facial symptoms. Group 1 had an average amplitude of 3.03 V (1–6.7), frequency of 148.26 Hz (10– 210), and pulse width of 221.37 µs (60–450). Group 2 had an average amplitude of 3.39 V (1.3–6), frequency of 143.93 Hz (40–235), and pulse width of 173.60 µs (60–500). Statistical significance was found when comparing voltage (P = 0.013) and pulse width (P = 0.0059), but not frequency (P = 0.5), between the two groups (Welch-modified two sample t-test, two sided, power = 0.91, and delta = 0.5). This suggests that more widespread dystonic symptoms may require higher voltage and lower pulse width for optimal control.

Our patient’s final parameters consisted of considerably higher voltage than the literature reported; this may be due to the longer follow-up since the previous work has demonstrated a consistent decrease in electrode impedance and voltage increase over time.[ 30 ] Interestingly, though her symptoms were largely cranial, our patient ultimately ended up with shorter pulse width than both groups.

This brief analysis has some limitations. Although this case represents some of the longest follow-up published for patient with blepharospasm, it remains just one case. Furthermore, our analysis of the cases in the literature combines a variety of short interval time points along with inconsistently reported patient outcomes. Regardless, we believe that this case demonstrates that there needs to be more research on the long-term course of programming in DBS patients, as well as developing new programming protocols to decrease the time until symptom control.


DBS of the GPi has repeatedly proven its efficacy in providing patients with relief of their dystonic symptoms when other medical therapies fail. It is thus unfortunate that this surgical intervention must often be accompanied by an extended period of stimulation parameter manipulations, as was the case for the patient we presented in this report. In an effort to provide guidance to an under-studied aspect of this treatment option, we provide descriptive statistics of the various stimulation parameters currently being used in the field to treat a wide range of dystonic symptoms with preliminary evidence suggesting isolated cranial blepharospasm tends to have lower voltage requirements with longer pulse widths when compared to more globalized dystonic phenotypes.

Declaration of patient consent

Patient’s consent not required as patient’s identity is not disclosed or compromised.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


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