Cephalohematomas, an occult nidus for infection and inflammation: A case report and review of the literature
- Department of Pediatric Neurosurgery, Advocate Children’s Hospital, Park Ridge,
- Department of Neurological Surgery, Loyola University Medical Center, Maywood, Illinois,
- Department of Neurosurgery, Children’s Hospital of the King’s Daughters, Norfolk, Virginia,
- Department of Pediatrics, Loyola University Medical Center, Maywood,
- Department of Neurosurgery, Carle Foundation Hospital, Urbana, Illinois, United States.
John Ta-Hsiang Tsiang, Department of Neurological Surgery, Loyola University Medical Center, Maywood, Illinois, United States.
DOI:10.25259/SNI_1158_2022Copyright: © 2023 Surgical Neurology International This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
How to cite this article: Daphne Li1,2, John Ta-Hsiang Tsiang2, Kimberly A. Mackey3, Andrew Bonwit4, Suguna Pappu5. Cephalohematomas, an occult nidus for infection and inflammation: A case report and review of the literature. 03-Feb-2023;14:38
How to cite this URL: Daphne Li1,2, John Ta-Hsiang Tsiang2, Kimberly A. Mackey3, Andrew Bonwit4, Suguna Pappu5. Cephalohematomas, an occult nidus for infection and inflammation: A case report and review of the literature. 03-Feb-2023;14:38. Available from: https://surgicalneurologyint.com/surgicalint-articles/12142/
Background: Cephalohematomas (CH) are benign neonatal fluid collections that arise between the periosteum and skull due to birth trauma, and usually resolve spontaneously without intervention. CH may rarely become infected.
Case Description: The authors report a case of sterile CH requiring surgical evacuation in a persistently febrile neonate treated with intravenous (IV) antibiotics for Escherichia coli urosepsis. Diagnostic tap of the CH yielded no pathogens, but given the persistence of fevers, surgical evacuation was performed. The patient demonstrated clinical improvement postoperatively.
Conclusion: A systematic review of literature was conducted through a MEDLINE search using the keyword “cephalohematoma.” Articles were screened for cases of infected CH and their subsequent management. Clinicopathological characteristics and outcomes of the present case were reviewed and compared to those in the literature. Infected CH were reported in 25 articles describing 58 patients. Common pathogens included E. coli and Staphylococcal species. Treatment included a course of IV antibiotics (10 days–6 weeks) and often included percutaneous aspiration (n = 47) for diagnostic and therapeutic purposes. Surgical evacuation was performed in 23 cases. To the authors’ knowledge, the present case is the first documented report in which evacuation of a culture-negative CH resulted in resolution of the patient’s clinical symptoms of sepsis that persisted despite appropriate antibiotic treatment. This suggests that patients with CH should be evaluated through diagnostic tap of the collection if there are signs of local or persistent systemic infection. Surgical evacuation may be indicated if percutaneous aspiration does not result in clinical improvement.
Keywords: Birth trauma, Cephalohematoma, Infection, Pediatric neurosurgery
Cephalohematomas (CHs) occur in 1–4% of live-births, often associated with birth trauma.[
A systematic MEDLINE search was conducted using the keyword “cephalohematoma.” The reference lists from these publications were examined for relevant literature and historical reports [
PRISMA flow diagram. Citations identified and evaluated on literature review of infected cephalohematomas. Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 6(7): e1000097. doi:10.1371/ journal.pmed1000097
Clinicopathological characteristics and outcomes of the present case were compared to those in the literature. The patient’s chart was reviewed for demographic data, clinical presentation, hospital course, relevant imaging, and follow-up using our electronic medical record system. Clinical case review was deemed not human subjects research and exempt from approval by our Institutional Review Board.
A male infant was born at term through uncomplicated vaginal delivery without instrument-assistance or fetal scalp electrodes. A left-sided CH was noted post-partum. At 3 weeks old, he presented to an outside institution with 1-day of fever, emesis, and diarrhea. He was started empirically on IV ampicillin and gentamicin, and infectious workup later revealed pan-sensitive E. coli bacteremia, urinary tract infection, and meningitis. After initial clinical improvement, he was transitioned to monotherapy with IV ampicillin. Shortly thereafter, he became febrile again, so cultures were redrawn and a head ultrasound performed, which was largely unrevealing. The patient was transferred to our institution for further management [
On arrival, he was noted to have a large, benign-appearing CH, and a reassuring physical examination, despite being febrile with a rising C-reactive protein (CRP). Magnetic resonance imaging (MRI) of the brain did not reveal any acute intracranial processes or definitive signs of CH infection [
(a-h) Magnetic resonance imaging (MRI) study of the patient’s brain on presentation to our institution. Select axial T2-weighted non-contrast (a), T1-weighted non-contrast (b), T1-weighted post-contrast (c), gradient echo (d), diffusion-weighted imaging (e), apparent diffusion coefficient (f), sagittal T1-weighted non-contrast (g), and coronal T1-weighted non-contrast (h) images from an MRI study of the patient’s brain. Images demonstrate a large heterogeneous extracranial fluid collection overlying the left parietal skull consistent with a cephalohematoma. The collection does have some enhancement along its margins, but does not demonstrate restricted diffusion. No significant surrounding subcutaneous edema is identified. No acute intracranial findings or abnormalities noted.
Documentation of patient’s vital signs during his admission at our institution. Patient’s body maximum temperature in °C (a) and median recorded heart rate (beats per minute; bpm) (b), as charted per nursing documentation for each 24-h period throughout the course of the patient’s admission. Patient continued to be intermittently febrile (>38°C or 100.4°F; red line) and tachycardic (>160 bpm; red line) until after the patient was taken to the operating room for surgical I&D of the cephalohematoma, on his 7th day of admission to our institution (grey rectangle).
Our patient became afebrile on postoperative day (POD)1 and remained clinically improved for the remainder of his hospitalization [
A MEDLINE search was conducted using the keyword “cephalohematoma.” Full-text, English-language articles were reviewed for management and outcomes of infected CH. This resulted in 25 publications, documenting 58 cases [
The majority of cases 52% (n = 30) had one or more concurrent infections,[
All patients were treated with IV antibiotics; some followed by a course of oral antibiotics. Duration varied from 10 days to 6 weeks, depending on concerns for osteomyelitis or other concurrent infections. The majority were treated with needle aspiration alone (n = 34/58).[
CH infection is rare and may occur early (<2 weeks of life) due to direct birth trauma or hematogenous seeding, or late (≥3 weeks of life) due to overlying cellulitis.[
Aspiration and surgical interventions are contraindicated in uncomplicated CH due to risks of contamination with bacteria.[
The presented case makes a unique contribution to the body of literature because this patient’s CH did not demonstrate evidence of infection on any diagnostic modality. It may be argued that because our patient received IV antibiotics for several days before needle aspiration or I&D, the CH may have been sterilized by appropriate treatment of pan-sensitive E. coli. There has been growing evidence for polymerase chain reaction testing of culture-negative fluid collections that are suspected to have harbored bacterial infections following initiating of empiric antibiotics. This test was not performed for our patient, but may be helpful to reveal a causative organism.[
Although the exact mechanism is unclear, the authors believe that CH evacuation was still indicated in this case given our patient’s persistent signs of systemic infection.
Optimal management of infected CH often requires a combination of IV antibiotics and evacuation. In the absence of clear local signs of infection, patients demonstrating a relapse or persistent signs of systemic infection should still be considered for definitive CH evacuation, even with negative cultures.
Ethics approval/consent to participate
Due to its retrospective nature, clinical case review was deemed not human subjects research and exempt from approval by the Loyola University Chicago Stritch School of Medicine Institutional Review Board (LU#213917) on July 22, 2020. Therefore, the Loyola University Chicago Stritch School of Medicine Institutional Review Board has waived the need for the patient’s and/or parents’/legal guardian’s written informed consent for publication. All included patient information has been deidentified.
Daphne Li is the first author having performed the majority of data extraction, literature review, data analysis, and writing of the manuscript. John Tsiang contributed to data analysis and drafting of the manuscript. John Tsiang, Kimberly Mackey, and Andrew Bonwit contributed to the critical review of the manuscript. Suguna Pappu is the principal investigator having contributed to the majority of design and review of the manuscript. All authors read and approved the final manuscript.
Patient’s consent not required as patient’s identity is not disclosed or compromised.
There are no conflicts of interest.
The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Journal or its management. The information contained in this article should not be considered to be medical advice; patients should consult their own physicians for advice as to their specific medical needs.
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