- Unit of Neurosurgery, “Di Venere” City Hospital, Bari, Italy
- Department of Neurosurgery, University “Magna Graecia”, Catanzaro, Italy
Unit of Neurosurgery, “Di Venere” City Hospital, Bari, Italy
DOI:10.4103/sni.sni_398_17Copyright: © 2018 Surgical Neurology International This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
How to cite this article: Domenico Murrone, Bruno Romanelli, Nicola Montemurro, Domenico Chirchiglia, Aldo Ierardi. Falcine meningioma in Von Hippel–Lindau disease: An unusual association. 14-Feb-2018;9:37
How to cite this URL: Domenico Murrone, Bruno Romanelli, Nicola Montemurro, Domenico Chirchiglia, Aldo Ierardi. Falcine meningioma in Von Hippel–Lindau disease: An unusual association. 14-Feb-2018;9:37. Available from: http://surgicalneurologyint.com/surgicalint-articles/falcine-meningioma-in-von-hippel-lindau-disease-an-unusual-association/
Background:Von Hippel–Lindau (VHL) disease is an autosomal dominant condition characterized by formation of multiple benign and malignant tumors. In this disease supratentorial lesions are rare and no falcine meningioma has been previously reported. Differential diagnosis is very difficult and the histopathological examination is the definitive method for diagnosis.
Case Description:A patient with VHL underwent a suboccipital craniotomy for removal of cerebellar hemangioblastoma and after 2 years magnetic resonance imaging (MRI) showed an iperintense solid mass located at posterior part of the falx. Histological diagnosis revealed meningioma.
Conclusion:The only case in the literature of falcine meningioma in a patient with Von Hippel–Lindau disease, discovered during radiological follow-up, is described and a surgical management is proposed.
Keywords: Falcine meningioma, hemangioblastoma, Von Hippel-Lindau disease
Von Hippel–Lindau (VHL) disease is a rare condition caused by genetic mutations on chromosome 3,[
A 55-year-old Caucasian female patient underwent a suboccipital craniotomy for removal of left cerebellar hemisphere HB. Abdominal computed tomography revealed a pheochromocytoma that was excised. Genetic analysis showed the presence of a VHL gene mutation and an evaluation of the family history demonstrated VHL disease in two of the patient's siblings. Thus this patient's condition had been diagnosed as VHL disease. Follow-up magnetic resonance imaging (MRI) performed 1 year after the first operation had shown no evidence of recurrence or abnormal findings in the supratentorial region [
Two years postoperative axial (a and b), sagittal (c and d), a coronal (e) T1-weighted MR images with gadolinium detecting a solid mass with strong enhancement in the right cerebellar hemisphere (yellow arrow) and an hyperintense extra-axial solid mass located at posterior part of the falx (green arrow)
Melmon and Rosen[
We report a rare case of asymptomatic slow-growing meningioma located at the third posterior of the falx in a patient with VHL, detected 2 years after surgical resection of a cerebellar HB, in which no surgical or radiotherapical treatment has been previously performed. In VHL, supratentorial meningeal masses are extremely rare and no other case of falcine involvement has been previously reported. Pathological and immunohistochemical techniques are helpful for differential diagnosis. Regular follow-up is mandatory and surgical resection is the definitive treatment for these lesions.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
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Conflicts of interest
There are no conflicts of interest.
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