- Department of Neurosurgery, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India,
- Department of Microbiology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India.
Correspondence Address:
Ahmed Ansari
Department of Microbiology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India.
DOI:10.25259/SNI_335_2020
Copyright: © 2020 Surgical Neurology International This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.How to cite this article: Ansari A1, Riyaz S2. Letter to the Editor: Transneural transmission in COVID-19 without a positive nasopharyngeal swab. Surg Neurol Int 12-Sep-2020;11:284
How to cite this URL: Ansari A1, Riyaz S2. Letter to the Editor: Transneural transmission in COVID-19 without a positive nasopharyngeal swab. Surg Neurol Int 12-Sep-2020;11:284. Available from: https://surgicalneurologyint.com/surgicalint-articles/10256/
We read with great interest the article by Bamps et al.[
Brain infection in COVID-19 patients is being seriously considered recently, owing to multiple reports of stroke, epilepsy, and encephalitis. ACE-2 expression in glia and neurons of brain is low, but well documented. SARS-CoV-2 invading high ACE-2 expressing non-neuronal olfactory epithelial cells is one such possibility and then passing to low ACE-2 expressing mature olfactory receptor neurons to be finally transported along olfactory axons to the brain. The lateral stria of olfactory tract carries axons to the primary olfactory cortex, located in the uncus of the temporal lobe. This can be argued as an important reason for the inflammation in medial temporal cortex and hippocampus in such patients. Although the first reported case of meningitis/encephalitis associated with CoV2 reports the use of antiviral drug laninamivir on the 2nd day with a negative test,[
Nevertheless, a more vigilant eye is required in this pandemic disease to have a better understanding of this entity.
Declaration of patient consent
Patient’s consent not required as there are no patients in this study.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
References
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2. Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis. 2020. 94: 55-8