- Department of Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, United States
- Department of Internal Medicine, The University of Chicago Pritzker School of Medicine, Chicago, United States
- Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States.
Olivia Kozel, Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States.
DOI:10.25259/SNI_1133_2022Copyright: © 2023 Surgical Neurology International This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
How to cite this article: Anusha Manjunath1, Chirag Goel1, Archit Bharathwaj Baskaran2, Olivia A. Kozel3, William Gibson1, Michael Jones1, Joshua M. Rosenow1. Spinal cord stimulation-induced gastroparesis: A case report. 21-Jul-2023;14:250
How to cite this URL: Anusha Manjunath1, Chirag Goel1, Archit Bharathwaj Baskaran2, Olivia A. Kozel3, William Gibson1, Michael Jones1, Joshua M. Rosenow1. Spinal cord stimulation-induced gastroparesis: A case report. 21-Jul-2023;14:250. Available from: https://surgicalneurologyint.com/surgicalint-articles/12455/
Background: Spinal cord stimulation (SCS) involves the utilization of an implantable neurostimulation device, stereotypically used in the treatment of patients with chronic neuropathic pain. While these devices have been shown to have significant clinical benefits, there have also been documented potential complications, including the risk of infection, fractured electrodes, electrode migration, and lack of symptom improvement. In addition, there has been minimal documentation on gastrointestinal (GI) side effects after SCS implantation.
Case Description: A 42-year-old patient with chronic axial and radicular neuropathic pain in her back and left leg status post multiple lumbar surgeries underwent implantation of an open paddle lead in the T8–T9 region. After the procedure, the patient endorsed a 50% decrease in pain at the 6-week follow-up with no further concerns. However, at the 18 months follow-up, the patient endorsed severe constipation when the SCS was turned on, leading to subsequent evaluation by gastroenterology, motility studies, and a thorough bowel regimen. Symptoms persisted, and the patient ultimately opted for the removal of the SCS implant at 21 months after the initial surgery.
Conclusion: While the exact mechanism behind the GI side effects endorsed in this patient is unknown, current literature postulates a variety of theories, including a SCS-induced parasympathetic blockade of the GI tract. Further, investigation is needed to determine the exact effects of SCS on the GI tract.
Keywords: Chronic neuropathic pain, Gastroparesis, Spinal cord stimulation
Spinal cord stimulation (SCS) is an implantable neurostimulation modality used for the management of chronic neuropathic pain.[
SCS as a therapeutic intervention is not without complications. Current literature details complications of SCS including infection, long-term hardware failure, fractured electrodes, electrode migration, epidural hematomas at implantation sites, urinary complications, and allergic cutaneous reactions to SCS devices.[
A 42-year-old female was seen at our hospital with chronic axial and radicular neuropathic pain in her back and left leg following multiple lumbar surgeries. Her verbal analog pain score averaged 8 on a scale of 0–10. In the past, she had used gabapentin, diazepam, long-acting morphine, hydrocodone/acetaminophen, and meloxicam without sustained relief. Lumbar epidural steroid injections, sacroiliac joint injections, and facet injections did not provide relief. At the time of presentation to our center, the patient had undergone a trial of SCS by an outside physician, which she stated reduced her pain by about 50%. Given this, it was deemed reasonable for the patient to consider a permanent SCS system implant.
The patient underwent an open paddle lead implant in the midline dorsal epidural space covering T8–T9 along with a primary cell generator. There were no complications from surgery. Six weeks out from the SCS system implantation, the patient reported that at rest, the SCS provided about 50% pain reduction. She was alternating between burst and sub-perception tonic programs. The patient did not complain of GI symptoms at the 6-week follow-up after the surgery. However, she presented 18 months after the implant with complaints of severe constipation when the SCS was turned on. She had been evaluated extensively by a gastroenterologist, undergone various motility studies, and reported having very consistent issues with poor bowel movements and abdominal pain only when the stimulator was on. When the stimulator was kept off for several days, her ability to voluntarily empty her bowels did recover. She tried a tonic stimulation program for 2 days but had a recurrence of symptoms. She then turned the stimulator off, reporting that her constipation symptoms improved markedly once the device was off again. When the stimulator was off, pharmacological treatment with laxatives, magnesium (750 mg/day), and cascara facilitated bowel movements. With the stimulator on, she had reasonable control of her baseline pain but required significant therapy to continue having bowel movements. She was told by a gastroenterologist that she would end up needing a colostomy bag if motility did not improve.
After several months of having the stimulator off and seeing continued improvement in her GI symptoms, the patient expressed her desire to have the device explanted since she was unable to use it. The procedure to remove the SCS system was performed about 21 months after the original system implantation. At subsequent visits to our hospital, the patient no longer had gastroparesis issues but recently underwent bowel surgery with diverting ileostomy for chronic rectal prolapse.
A search of the PubMed database revealed only two case reports in the literature as of April 2021 that discuss GI effects resulting from SCS.[
It is known that significant GI symptoms can result from spinal cord injury.[
A case report by La Grua describes a patient with SCS and concomitant GI symptoms.[
Parasympathetic innervation to the distal colon largely originates from the sacral spinal cord, primarily from the S1 to S4 regions.[
Damage to these parasympathetic neurons can result in irregular colonic motility as well as constipation.[
SCS has been used for many years as a modality for pain management. In the case study presented, the patient’s GI symptoms directly correlated with the amplitude of stimulation from the SCS device. Although the exact mechanisms through which the GI symptoms occurred are unknown, a potential mechanism could involve SCS-induced parasympathetic blockade of the GI tract. Future studies are necessary to specifically examine the effects of SCS on the GI system.
Patient’s consent not required as patient’s identity is not disclosed or compromised.
There are no conflicts of interest.
The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Journal or its management. The information contained in this article should not be considered to be medical advice; patients should consult their own physicians for advice as to their specific medical needs.
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