Nada Alnefaie, Othman T. Almutairi, Abdulrahman Y. Alturki, Mohammed Bafaquh
  1. Department of Adult Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.

Correspondence Address:
Othman T. Almutairi, Department of Adult Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.


Copyright: © 2022 Surgical Neurology International This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Nada Alnefaie, Othman T. Almutairi, Abdulrahman Y. Alturki, Mohammed Bafaquh. Bibliometric analysis of the top 100 most-cited articles in neurofibromatosis. 01-Jul-2022;13:282

How to cite this URL: Nada Alnefaie, Othman T. Almutairi, Abdulrahman Y. Alturki, Mohammed Bafaquh. Bibliometric analysis of the top 100 most-cited articles in neurofibromatosis. 01-Jul-2022;13:282. Available from:

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Background: Neurofibromatosis (NF) is an umbrella term that refers to three distinct disease entities: NF Type 1, Type 2, and schwannomatosis. Here, we reviewed the scientific performance and the most influential publications on NF.

Methods: A keyword-based search was performed using the Scopus database. The top 100 articles were grouped based on NF types and the studied entities. The differences between the articles, authors, and journals were quantified based on certain parameters. Other parameters were collected for the complete citational analysis.

Results: The top 100 articles were published between 1961 and 2020. The most trending period of research was in the 1990s and articles studying the clinical aspect and the underlying genetic correlation made up 84% of all articles from the list. The United States of America (USA) had the highest number of contributions (69 articles, 69%). The top institute of contribution to the list was the Howard Hughes Medical Institute, USA (14 articles, 14%). Author-based analysis reveals that the neurologist D. H. Gutmann from St. Louis Children’s Hospital, USA, was the most active and authored 11 articles (11%) on the list.

Conclusion: The publication trends show that articles studying medical and surgical management were of little interest. The top 100 articles did not include any randomized control trials, and the highest level of evidence was obtained from reviews of pooled knowledge as well as population-based and longitudinal studies.

Keywords: Bibliometric, Neurocutaneous disorders, Neurofibroma, Neurofibromatosis, Von Recklinghausen disease


The term neurofibromatosis (NF) was first introduced to the medical literature by Frederick von Recklinghausen in 1882 to characterize the structural relation and mutual involvement of neuromas and fibromas. [ 20 , 100 ] NF Type 1 (NF1) and Type 2 (NF2) are both dominantly inherited; nonetheless, they are distinct disease entities.[ 53 , 85 ] NF1 is caused by a mutated tumor suppressor gene on the long arm of chromosome 17 (17q11.2).[ 8 , 117 ] The disorder is most commonly defined by the cutaneous stigmata, café-au-lait spots, and neurofibromas.[ 42 ] NF2 is caused by a different mutated gene on the long arm of chromosome 22 (22q1.2) and is characterized by the development of multiple neurologic lesions as well as cutaneous and ocular manifestations.[ 99 , 113 ] The overall reported rates of NF1 and NF2 are 1/3000 and 1/25,000, which make them relatively rare diseases.[ 34 , 39 ] The National Institutes of Health (NIH) in 1987 (updated in 1997) identified the diagnostic criteria of NF1 and NF2 after which the ambiguity between the two types has considerably resolved in the literature.[ 53 , 85 ]

A major type of NF and challenging differential of NF2 are schwannomatosis, also known as NF Type 3 (NF3).[ 77 ] The reported incidence of schwannomatosis is 1/68,956, which is less than half the incidence of NF2.[ 36 ] Unlike NF2, schwannomatosis is caused by mutated SMARCB1 and LZTR1 on chromosome 22 and delineated by multiple non-intradermal schwannomas and the absence of bilateral vestibular schwannomas.[ 56 , 89 ]

The management of NF involves many disciplines.[ 85 ] Medically, to date, there is no specific curable pharmacological treatment for NF1, but trials to treat some of the clinical manifestations are ongoing.[ 31 , 51 , 54 ] Recently, a mitogen-activated protein kinase inhibitor (Selumetinib) was approved, but its use is currently limited to children with plexiform neurofibroma.[ 79 ] For NF2, targeted therapy for the progressive vestibular schwannoma is promising.[ 13 , 63 , 70 , 90 , 91 ] Even so, there is no specific therapeutic agent yet approved.

Bibliometric analysis is an objective method to evaluate scientific publications’ performance in various fields.[ 10 , 119 ] Publication data are analyzed through multiple indicators to measure the impact, and more precisely, the effect of utility.[ 119 ] Citations are votes that often reflect the importance and reputation of a scientific paper.[ 10 , 119 ] Similar bibliometric studies have been published previously.[ 1 , 2 , 33 , 125 - 129 ] The top 100 cited articles will be discussed in this study, and their significant results and impact on the NF field will be detailed.


A bibliometric keyword-based search using the Scopus database was utilized to perform a citation analysis of the top 100 most-cited articles on NF. A title-specific search using “NF,” “neurofibroma,” and “von Recklinghausen’s” was performed as search terms. The articles were rearranged based on their citation count (CC) in descending fashion. The top 100 articles were collected after excluding non-English, conference papers, erratum publications, and unpublished articles. The list of the top 100 articles on NF was categorized based on NF types to Type 1 and Type 2. Further subcategorization based on the studied entities of the top 100 articles yielded the following categories: (1) clinical, (2) genetics, (3) experimental, (4) histopathological, (5) radiological, (6) medical management, and (7) surgical management. The following parameters were considered when quantifying the difference between articles, authors, and journals: CC, citation per year (CY), Journal’s SCImago Journal Rank (SJR), Journal’s Source Normalized Impact Per Paper, Hirsch index (H-Index), and Journal Impact Factor (IF). The H-Index measures the productivity and the impact of an author by calculating the number of publications, he has been cited for at least the same number of times.[ 57 ] The Journal IF is defined as the average count of citations received in a given year per article published in the preceding 2 years.[ 48 , 50 ] Other significant parameters of interest were collected for the complete citational analysis of publications, which involved the authors, first author’s specialty, article title, country of origin, contributing institutions, journals, and year of publications. Furthermore, a two tailed correlation analysis at 5% level of significance was carried out between the number of citations and the duration of publication in an Excel spreadsheet and SPSS version 26. Selection of the studies included in the discussion section was based on the following criteria to establish narrative review: 1 – highly cited article in relation to other articles within the same category, 2 – the degree of scientific contribution, and 3 – historical or scientific relevance to the top cited articles.


The keyword-based search identified 12,718 articles in which 8564 articles were included after excluding mismatched articles. The publication dates ranged from 1906 to 2020 in which the top 100 articles were published between 1961 and 2020. The top 100 articles CC accounted for 28,957 CCs; the self-citations rate was 7.56%, and the citations from books were 8.21% [ Table 1 ]. The top ten most-cited articles are listed [ Table 2 ]. The most trending research period was the 1990s in which 54 articles from the list were published [ Figure 1 ]. Articles studying the clinical (44%) aspect and the underlying genetic (40%) correlation constituted 84% of all articles from the list. The remaining 16% are histopathological (4%), experimental (8%), radiological (2%), surgical (1%), and medical (1%) management articles. The United States of America had the highest number of contributions to the list at 69 articles. The top institutes of contribution to the list showed that Howard Hughes Medical Institute was highest and produced 14 articles from the list [ Figure 2 ]. Journal-based analysis showed that four journals had an IF range of 38.63 to 70.67. Cell was the most contributing journal and published nine articles from the list; it has the highest SJR score among the top journals [ Figure 3 ]. The author-based analysis reveals that the neurologist D.H. Gutmann was the most active and published 11 articles on the list. The highest H-index was a paper from the geneticist F.S. Collins at 177 [ Figure 4 ]. The most-cited article was authored by Wallace et al., in 1990, by Science where they studied the large transcript disruption in NF1 subjects. The article was cited 1114 times and had a CY of 37.1.[ 117 ] Results of the two tailed correlation test indicate a statistically significant (P = 0.013) relationship between the number of years since an article was published and its CC (correlation coefficient = 0.247). The same result was also obtained by inspecting the scatterplot which supported the test results [ Figure 5 ].

Table 1:

The top 100 most-cited articles on neurofibromatosis.


Table 2:

The top 10 most-cited articles on neurofibromatosis.


Figure 1:

The publications trends in neurofibromatosis.


Figure 2:

The most contributing institutes.


Figure 3:

The most contributing journals.


Figure 4:

The most contributing authors.


Figure 5:

The scatterplot shows a positive relationship between the two variables, correlation coefficient of r = 0.247 (P = 0.013).



In the 1960s to 1986, NF publications focused on the pathological and clinical aspects. The association of NF to soft-tissue sarcoma, vascular lesions, and other types of malignancies was of great interest. Clinically, the literature offered updates on the current state of knowledge, established familiarity, and highlighted controversies and gaps for the future research.

In 1987–1997, the publications’ focus remarkably shifted toward discussing molecular pathogenesis and its biological behaviors. In this decade, the literature was dominated by genetic discoveries including population-based and prospective longitudinal studies. After 1997, clinical and experimental publications took over the trend with particular attention to the associated risks, epidemiology, and multidisciplinary management approach.

The top three highly cited articles in the NF field

The most-cited article involved the discovery of the gene responsible for NF1 (17q11.2) with 1114 CC and 37.1 CY. The article was published in Science under the genetic studies category. In 1990, Wallace et al. isolated and cloned the responsible NF1.[ 117 ]

The second most-cited article was published in the Journal of the American Medical Association and was a clinical study.

This had updated recommendations on NF diagnosis and management with 1028 CC and 44.7 CY. A thorough and systematic review of the NF literature between 1966 and 1996 was performed by the NF Clinical Care Advisory Board members and published in 1997.[ 53 ] These recommendations were different from the previous one founded in 1987 by NIH 4 in the following: (1) it was published 4–5 years after the discovery of NF1 and NF2 implicated genes. Therefore, the recommendations were set in the insight into the genetic advances of the disease. (2) They founded slightly different clinical diagnostic criteria of NF2 and introduced the categories of confirmed and presumptive NF2, through which they have widened the diagnosis window of the disease. (3) More comprehensive approach to management was proposed. However, the recommendations asserted on the clinical diagnostic criteria of NF1 were founded initially by NIH.[ 85 ]

The third most-cited article was the identification, isolation, and cloning of the NF2 gene. The article was published in Cell under the genetic studies category with 1014 CC and 37.6 CY. In 1993, Trofatter et al. successfully identified the NF2 gene in which they also found it to be altered in meningiomas.[ 113 ]

NF publications by category


In the late 20th century, publications were devoted to establishing a panoramic understanding of NF prevalence, natural history, specific clinical features, associated clinical disorders, and prognosis. In the early 21st century, the literature focused on the clinical category and slightly shifted to NF-associated risk of malignancy, management insights, and more in-depth knowledge about the disease epidemiology.[ 6 , 15 , 17 , 28 , 35 , 40 , 41 , 44 - 47 , 52 , 58 , 60 , 61 , 62 , 64 , 66 , 69 , 73 - 76 , 84 , 86 - 88 , 94 , 95 , 97 , 98 , 102 , 103 , 107 , 111 , 112 , 114 - 116 , 118 , 121 , 124 ]

The second highly cited article in this category (ranked fourth overall with 913 CC and 23.4 CY) was a review article of NF authored by Riccardi and published in the New England Journal of Medicine (1981). In his review, Riccardi offered comprehensive NF information sources including its clinical features, hypothesized pathogenesis, laboratory features, gaps in knowledge, and a recommended approach of management.[ 96 ] Although the review was not conducted systematically and bias cannot be ruled out, the careful selection of information sources from extensive surveys and prospective studies is useful. The paper was also written before the NIH statement on NF diagnostic criteria in 1987. Hence, the term “classical NF” (i.e., NF1) was used to differentiate it from “bilateral acoustic NF” (i.e., NF2).[ 85 , 96 ]

Complementing Riccardi’s review and after NIH diagnostic criteria have been established (1987), Martuza and Eldridge published a review article of NF2 in the New England Journal of Medicine in 1988, (376 CC, 11.8 CY, ranked 22nd overall). The article added a valuable contribution to NF literature by distinguishing NF2 in light of the most updated diagnostic criteria.[ 81 , 85 ]

The third highly cited article in the clinical studies category was ranked 8th overall with 711 CC and 39.5 CY. A population-based and longitudinal study published in the Journal of Medical Genetics (2002) and was authored by Evan et al. In light of conflicting reports discussing rates of malignant peripheral nerve sheath tumors (MPNST) among NF1, this study investigated the survival rates and lifetime risk of MPNST in NF1 patients for 13 years (1984–1994). The data of MPNST and NF1 patients were obtained from regional cancer and genetic registries. The annual risk of MPNST in NF1 patients was 1.6/1000 and the estimated risk of a lifetime was 8–13%.[ 35 ] Concurrently, a comprehensive international statement based on expertise and available evidence from the literature was published in the Cancer Research journal in 2002 (383 CC, 21.3 CY, ranked 21st overall). The statement highlighted the features that should raise the suspicion of underlying malignancy in NF1 patients. They also recommended increased surveillance of MPNST in NF1 patients with plexiform neurofibroma and discussed the usefulness of variable imaging and molecular studies.[ 35 , 41 ]

Given the genetic basis and hereditary nature of NF of all types, population-based studies played a significant role in understanding the disease epidemiology and identifying patients at risk. The fourth highly cited article in the clinical studies’ category (ranked 12th overall) was a population-based study of NF1 authored by Huston et al. and published in Brain in 1988 (511 CC, 16 CY). The NF1 prevalence was 0.02% (1 in 5000). In addition to café-au-lait spots, axillary (64%) and groin (44%) freckling were standard associated features. Plexiform neurofibroma was identified in 32% of the cohort. The survey was conducted before the NIH diagnostic criteria of NF1; therefore, the criteria used did not include Lisch nodules, bony dysplasia, nor optic pathway glioma. However, Huston et al. selected the highly sensitive clinical features of NF1 and mentioned the recently established diagnostic criteria at the time, the paper was published.[ 60 , 85 ]

A similar population-based study on NF2 was performed (ranked 17th overall). The paper was published in the Quarterly Journal of Medicine, in 1992, and authored by Evan et al. (486 CC, 17.4CY). A comprehensive and regional method of data collection was conducted between 1989 and 1992. The reported age of onset was 21.57 years. Deafness was present in almost half of the cases; 80% was unilateral. Caféau-lait spots and nodular cutaneous manifestations were common findings at 43% and 68%.[ 37 ] A significant finding was the poor survival rate. Forty patients (39%) died because of NF2-related complications with a mean age of 36.[ 37 ]

The eighth highly cited article in the clinical category (Ranked 20th overall) with 394 CC and 15.2 CY was authored by Listernick et al. and published in the Journal of Pediatrics (1994). A prospective and longitudinal study was conducted between 1985 and 1993. The primary goal was to determine the natural history of the optic pathway tumor (OPT) in children with NF. Repeated imaging and clinical exams in this subgroup of patients — with a median follow-up of 2.4 years and 3.4 years — confirmed a benign natural history with no evidence of either tumor growth or visual deterioration. Although a minority of cases progressively worsened, the study concluded that the risk of developing rapidly progressive OPT is at its greatest during the first 6 years of life, and regular ophthalmologic screening is recommended among this age group.[ 73 ]


In the late 1980s, genes implicated in NF1 and NF2 were located on 17q11.2 and 22q1.2. Shortly after, the defective genes were identified, isolated, and cloned in multiple synergetic studies in 1990. These discoveries provided a groundwork for further studies to be performed on the encoded protein. Subsequently, and for over a decade, publications in the genetic category were directed toward a deeper understanding of the intermolecular interactions, molecular pathogenesis, phenotypic, genotypic correlation, and variations. [ 3 , 4 , 5 , 7 , 11 , 12 , 14 , 16 , 18 , 19 , 21 , 23 , 27 , 29 , 32 , 38 , 43 , 55 , 59 , 65 , 68 , 72 , 78 , 83 , 104 - 106 , 108 , 109 , 114 , 116 , 120 , 122 , 123 ]

Xu et al. authored the fourth highly cited article in the genetic studies category (Ranked sixth overall; Cell in 1990 with 838 CC and 27.9 CY). It described the discovery of the cloned NF1 gene peptide. The peptide had a 360 residue long sequence of amino acids similar to guanosine triphosphate hydrolase stimulatory proteins (GAPs).[ 123 ]

The sixth highly cited article in the genetic studies (ranked ninth overall) discovered a critical intermolecular interaction of the NF1 gene-encoded peptide. The study was authored by Martin et al. and published in Cell in 1990 with 683 CC and 22.8 CY. The GAP domain of the NF1 peptide enhanced the intrinsic GTPase activity of the intercellular P21ras protein. This finding hypothesized the encoded protein’s role in down-regulating and controlling cellular proliferation — a regular function that might have been impaired because of a mutated NF1 gene.[ 80 ] This theory was supported further in the seventh highly cited article in the genetic studies category (Ranked 10th overall), which was authored by Basu et al. and published in Nature journal in 1992, (529 CC, 18.9 CY).[ 9 ]

A population-based genetic study was performed in 1992 to complement the previous clinical study of NF2.[ 37 ] This follow-up study was authored by Evans et al. and published in the Journal of Medical Genetics (ranked 27th overall, 358 CC, 12.8 CY). The results confirmed the dominance pattern of inheritance. Furthermore, the affected members of one family were found to have similar phenotypic expressions. Furthermore, maternally inherited NF2 was associated with an earlier onset and the development of more severe forms of the disease.[ 38 ]

The mutations implicated in severe NF2 were investigated in another study. Frame shift-deletion/insertion mutations (i.e., protein-truncating mutations) were found to be associated with severe forms. Nevertheless, missense mutations were more likely to cause milder NF2 manifestations. These findings were reported by Ruttledge et al. and published in the American Journal of Human Genetics in 1996 (ranked 82nd overall, 210 CC, 8.8 CY).[ 101 ]


Eight articles were identified in this category. All articles were published between the late 1990s and mid-2000s. Two major clinical problems were investigated in mice models. The first was learning difficulties and cognitive deficits in NF1. The second was tumor development in NF1 and NF2.[ 13 , 22 , 26 , 71 , 72 , 93 , 110 , 115 ]

The reported rates of cognitive deficits and learning disabilities in children with NF1 are higher than their regular counterparts. This domain was investigated by the highly cited article in the experimental studies category (Ranked 19th overall) on mice models. The article was authored by Costa et al. and published in Nature (2002; 411 CC and 22.8 CY). The experiment was performed on mice with an induced NF1 heterozygous null mutation. The mice carrying this mutated gene expressed learning deficits that were responsive to genetic and pharmacologic suppression of Ras activity and, subsequently, the implicated increased GABA mediated inhibition. This experiment postulated that learning disabilities in NF1 affected individuals and might be reversed through targeting this molecular pathway.[ 24 ]

Tumor development in NF2 was investigated in the fourth highly cited article in this category (ranked 51st overall). The study was authored by Giovannini et al. and published in Genes and Development (2000; 270 CC and 13.5 CY). The experiment used on mice models to show that schwannoma development requires two mutated alleles to express this phenotype. The mutated NF2 gene is also involved in the development of multiple neurocristopathies.[ 49 ]


D’Agostino et al. authored the highest cited article in histopathological studies (ranked 49th overall). Furthermore, it published in Cancer (1963; 276 CC and 4.8 CY). A retrospective and descriptive report of clinical course and histopathological findings of 21 patients with NF1. The report was one of earliest articles that detailed the cases’ general profile, clinical manifestations, pathological findings, treatment, and clinical course. The high number of citations could be contributed to two reasons. First is the noticeable trending period of research investigating the association of NF to soft-tissue sarcoma and other malignancies between 1960s and 1986. Second is the possible correlation between the publication date and the number of citations.[ 25 ]


In the radiological studies category, two studies were in the top 100 list and were ranked 89th and 91st overall. The first paper (ranked 89th overall) was authored by Dipaolo et al. and published in Journal of Radiology (1995) with 206 CC and 8.2 CY. Brain autopsy findings in three NF1 patients were correlated with the findings on T2-weighted images.[ 30 ] The second paper in the category (ranked 91st overall) discussed the clinical and radiological aspects of NF2 with particular attention given to imaging lesions. The article was authored by Mautner et al. and published in Neurosurgery (1996; 205 CC and 8.5 CY). Thorough clinical and radiological (MRI with contrast) evaluation was performed on 48 NF2 individuals diagnosed based on the NIH criteria. Significant observations were the high frequency of vestibular schwannomas (>90%) and, most importantly, spinal lesions (90%) detected on imaging. Given the relatively subtle and heterogeneous presentation of NF2, the study recommended “properly NF2” patients to be followed.[ 82 ]

Medical management

In the medical management category, only one study was in the top 100 highest cited articles in NF (ranked 50th overall). The article was authored by Plotkin et al. and published in New England Journal of Medicine in 2009 with 270 CC and 24.5 CY. In this study, immunohistochemical analysis of the proportion of receptors expressed in NF2 vestibular schwannoma samples and sporadic schwannomas as controls were performed. Vascular endothelial growth factor (VEGF) receptors were found to be expressed in all NF2 vestibular schwannomas (21/21) and VEGFR-2 in 32% (7/21). Patients who were poor candidates for the standard treatment were offered bevacizumab — an anti-VEGF antibody. Among the patients’ treated, an imaging response was seen in 60% of subjects (6/10). Clinically, a hearing response was evident in 57% (4/7).[ 92 ]

Surgical management

The surgical management of a 29-year-male with diffuse facial plexiform neurofibroma who underwent composite tissue allograft facial transplantation was detailed by Lantieri et al. and published in The Lancet in 2008 (94th overall) with 203 CC and 16.9 CY. The article addressed surgical management and the postoperative course including immunosuppressive therapy and graft rejection monitoring. The benefits overweigh the risks in this case, which made the allotransplantation a possible treatment option in similar selected cases.[ 67 ]

Limitations and strengths

The top 100 articles were extracted from a single database, which could have added bias to the data presented. In addition, the correlation test performed showed that the older a published article is the more its citated. A positive correlation of 0.2 is, however, weak which indicates the presence of other factors that could have influenced the number of citations.


We provided a historical reference with a recognized pattern for the future research in the field of NF. If complemented with reviews from expertise, bibliometric studies can be utilized to predict future research directions and identify gaps in evidence.


We have presented the top 100 most influential publications on NF. Most articles addressed clinical and genetic aspects. In addition to extensive surveys and prospective and longitudinal studies, multidisciplinary statements produced from pooled evidence and expertise provided the highest level of evidence in these articles.

Declaration of patient consent

Patient’s consent not required as there are no patients in this study.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


We want to thank the American Manuscript Editors for English language editing (


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